![]() ![]() A possible current example is dilated cardiomyopathy (DCM) in dogs in the US following prolonged intake over months or years of grain-free, legume-rich diets. However, these may change the bioavailability or metabolism of nutrients and other dietary components, potentially leading to health issues. Recent years have shown an increasing trend in the use of less traditional (alternative) feed ingredients in pet foods. The data will aid in generating hypotheses for future studies. Changes in taurine metabolism were indicated. ![]() Thus grain-free, legume-rich Test diets caused reduced RBC and hyperphosphatemia, findings also indicated in dogs with suspected DCM. Regarding taurine status, Test dogs transiently increased whole-blood (23.4%) and plasma (47.7%) concentrations on day 14, while taurine:creatinine ratio in fresh urine and taurine in pooled urine were reduced by 77 and 78%, respectively, on day 28/30. Commonalities in these parameters were observed in clinical DCM cases. Compared to baseline values, feeding the Test diet for 28 days caused progressive, significant ( p < 0.001) decreases in red blood cell counts (RBC), hematocrit and total hemoglobin by 7.7, 8.3 and 6.3%, respectively, and a 41.8% increase in plasma inorganic phosphate. The EHRs of dogs at Banfield® Pet Hospitals in the 2-year period 2018-2019 were surveyed, revealing 420 dogs diagnosed with DCM, which were compared with 420 breed, gender and age-matched healthy control dogs. Blood and urine samples collected at baseline and days 3, 14 and 28/30 were analyzed for hematology, clinical biochemistry and taurine concentrations. Control and Test diets were fed to Labrador retriever dogs for 30 days ( n = 5 and 6, respectively). To help understand the clinical relevance of the findings, a survey of electronic health records (EHR) was conducted of dogs with and without suspected DCM for comparison. ![]() Early responses in healthy adult dogs fed grain-free diets with high inclusion of split peas (20%) and lentils (40%) that may lead to canine diet-induced dilated cardiomyopathy (DCM) were investigated. ![]()
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